Hypertension Essay -- Health, Cardiovascular Diseases, Stroke

Hypertension is one of the major risk factors for the maturement of cardiovascular diseases including stroke and may also have a role in the development of vascular cognitive impairment and vascular dementia 1, 2. angiotonin I-converting enzyme (EC 3.4.15.1 ACE) plays an important role in the rennin-angiotensin system and it is a carboxyl-terminal dipeptidyl exopeptidase that catalyzes the conversion of angiotensin I to angiotensin II 3-6. ACE converts an inactive form of decapeptide, angiotensin I, to a potent vasoconstrictor, octapeptide, angiotensin II, in addition since the ACE is a multifunctional enzyme it also catalyzes the degradation of bradykinin, which is known as a vasodilator 4, 7. Therefore, quelling of ACE activity leads to decrease in the concentration of angiotensin II and increases the level of bradykinin consequently reduce blood pressure 8. The discovery of captopril as a potent inhibitor of ACE led to the recent development of many series of novel structures with similar biological activity 9. To check a wide variety of ACE inhibitors from various land and shipboard soldier food sources have been reported such as milk 10, discontinue 11, egg white 12, canola 13, peanut 14, rapeseed 15, antler 16, fish muscle 17, seaweeds 18 and tuna 2. numerous academic, scientific, and regulatory organizations are considering ways to establish the scientific basis to tin and further validate claims for functional components or the foods containing them. Consumer interest in the blood between diet and health has increased the demand for information near functional foods. More recently, the food industry, the agricultural community, and now consumers have shown a growing interest in the field of... ...dependent on the conversion of color tetrazolium bromide to its purple formazan derivative by mitochondrial succinate dehydrogenase in viable cells 34. In conclusion, E. cava is a very interesting resource, due to the presence of unique phlorotannin derivatives with superfluous bioactivities including ACE inhibitory activity. Ethanol enhances the extraction of phlorotannins specially dieckol from the brown seaweed E. cava. By contrast, in this study phloroglucinol derivative dieckol exhibited the strongest activity against ACE. With the results of this study we can advise that the brown seaweed E. cava could be used in development of promising and effectiveness functional food products. Moreover, it is expected that these findings will contribute to developing interests in basic research and potential applications of the phlorotannins in the relevant fields.